Publications

TB Poulsen Laboratory

Publications

 

33. T. Salomón, C. Sibbersen, J. Hansen, D. Britz, M. V. Svart, T. S. Voss, N. Møller, N. Gregersen, K. A. Jørgensen, J. Palmfeldt, T. B. Poulsen*, M. Johannsen*

”Ketone Body Acetoacetate Buffers Methylglyoxal via a Non-enzymatic Conversion during Diabetic and Dietary Ketosis”,

Cell Chem. Biol. 2017, doi: 10.1016/j.chembiol.2017.07.012 [Link]

 

 

 

 

 

 

 

 

 

 

 

 

 

 

32. E. F. Holmquist, U. B. Keiding, R. Kold-Christensen, T. Salomón, K. A. Jørgensen , P. Kristensen, T. B. Poulsen, M. Johannsen*

"ReactELISA: Monitoring a Carbon Nucleophilic Metabolite by ELISA—a Study of Lipid Metabolism"

Anal. Chem. 2017, 89, 5066-5071. [Link]

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

31. N. L. Villadsen, K. M. Jacobsen, U. B. Keiding, E. T. Weibel, B. Christiansen, T. Vosegaard, M. Bjerring, F. Jensen, M. Johannsen, T. Tørring*, T. B. Poulsen*

"Synthesis of ent-BE-43547A1 reveals a potent hypoxia-selective anticancer agent and uncovers the biosynthetic origin of the APD-CLD natural products"

Nat. Chem. 2017, 9, 264-272. [Link]

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

30. H. Feinberg, N. D. S. Rambaruth, S. A. F. Jégouzo, K. M. Jacobsen, R. Djurhuus, T. B. Poulsen, W. I. Weis, M. E. Taylor, K. Drickamer*

"Binding Sites for Acylated Trehalose Analogs of Glycolipid Ligands on an Extended Carbohydrate Recognition Domain of the Macrophage Receptor Mincle"

J. Biol. Chem. 2016, 291, 21222-21333. [Link]

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

29. M .Tsakos, K. M. Jacobsen, W. Yu, N. L. Villadsen, T. B. Poulsen*

"The Rakicidin Family of Anticancer Natural Products – Synthetic Strategies towards a New Class of Hypoxia-Selective Cytotoxins"

Synlett. 2016, 27, 1898-1906. [Link]

 

 

 

 

 

 

 

 

 

 

 

 

28. W. Yu, P. Hjerrild, J. Overgaard, T. B. Poulsen* "A Concise Route to the Strongylophorines"

Angewandte Chemie, Int. Ed. 2016, 55, 8294-8298. [Link]

 

 

 

 

 

 

 

 

 

 

Featured in Synfacts

Featured in Organic Chemistry Highlights

 

27. M. Tsakos, L. L. Clement, E. S. Schaffert, F. N. Olsen, S. Rupiani, R. Djurhuus, W. Yu, K. M. Jacobsen, N. L. Villadsen, T. B. Poulsen*

"Total Synthesis and Biological Evaluation of Rakicidin A and Discovery of a Simplified Bioactive Analogue"

Angewandte Chemie, Int. Ed. 2016, 55, 1030-1035. [Link]

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Featured in Synfacts

26. F. N. Olsen, M. Tsakos, T. B. Poulsen*

"Npys-Mediated Elimination Reactions of Alcohols and Thiols: A Facile Route to Dehydroalanine and Dehydrobutyrine Building Blocks"

Synlett, 2015, eFirst, DOI: 10.1055/s-0035-1560537. [Link]

 

 

 

 

 

 

 

 

 

 

25. M. Gruca, W. Yu, P. Amoateng, M. A. Nielsen, T.B. Poulsen, H. Balslev*

"Ethnomedicinal survey and in vitro anti-plasmodial activity of the palm Borassus aethiopum MartEthnomedicinal survey and in vitro anti-plasmodial activity of the palm Borassus aethiopum Mart"

J. Ethnopharmacol. 2015, 175, 356-369. [Link]

 

24. L. L. Clement, M. Tsakos, E. S. Schaffert, C. Scavenius, J. J. Enghild, T. B. Poulsen*

"The amido-pentadienoate-functionality of the rakicidins is a thiol reactive electrophile – development of a general synthetic strategy"

Chem. Commun. 2015, 51, 12427-12430. [Link]

 

 

 

 

 

 

 

 

 

 

 

23. M. Tsakos, E. S. Schaffert, L. L. Clement, N. L. Villadsen, T. B. Poulsen*

"Ester Coupling Reactions - An Enduring Challenge in the Chemical Synthesis of Bioactive Natural Products"

Nat. Prod. Rep. 2015, 32, 605-632. [Link]

 

 

 

 

 

 

 

 

 

 

 

 

Featured by NPR as Editor's Choice for 2015

 

 

22. K. M. Jacobsen, U. B. Keiding, L. L. Clement, E. S. Schaffert, N. D. S. Rambaruth, M. Johannsen, K. Drickamer*, T. B. Poulsen*

"The Natural Product Brartemicin is a High Affinity Ligand for the Carbohydrate-Recognition Domain of the Macrophage Receptor Mincle"

Med. Chem. Commun. 2015, 6, 647-652. [Link]

 

 

 

 

 

 

 

 

 

 

21. T. B. Poulsen*

"A Concise Route to the Macrocyclic Core of the Rakicidins"

Chem. Commun. 2011, 47, 12837-12839 [Link]

 

 

 

 

 

 

 

 

 

Post Doc (Harvard - MD Shair Laboratory)

20. A. W. G. Burgett, T. B. Poulsen, K. Wangkanont, D. R. Anderson, C. Kikuchi, K. Shimada, S. Okubo, K. C. Fortner, Y. Mimaki, M. Kuroda, J. P. Murphy, D. J. Schwalb, E. C. Petrella, I. Cornella-Taracido, M. Schirle, J. A. Tallarico, M. D. Shair, "Natural Products Reveal Cancer Cell Dependence on Oxysterol-Binding Proteins", Nat. Chem. Biol. 2011, 7, 639-647.

 

Post Doc (Aarhus - KA Jørgensen Laboratory)

19. G. Dickmeiss, V. De Sio, J. Udmark, T. B. Poulsen, V. Marcos, K. A. Jørgensen, "Organocatalytic Asymmetric Desymmetrization-Fragmentation of Cyclic Ketones"Angew. Chem. Int. Ed.2009, 48, 6650-6653.

18. D. G. Alberg, T. B. Poulsen, S. Bertelsen, K. L. Christensen, R. D. Birkler, M. Johannsen, K. A. Jørgensen, "Organocatalysis with Endogenous Compounds: Towards Novel Non-enzymatic Reactions"Bioorg. Med. Chem. Lett.2009, 19, 3888-3891.

PhD (Aarhus - KA Jørgesen Laboratory)

17. C. B. Madsen, L. B. Madsen, S. S. Viftrup, M. P. Johansson, T. B. Poulsen, L. Holmegaard, V. Kumarappan, K. A. Jørgensen, H. Stapelfeldt, "A Combined Experimental and Theoretical Study on Realizing and Using Laser Controlled Torsion of Molecules" J. Chem. Phys.2009, 130, 234310.

16. C. B. Madsen, L. B. Madsen, S. S. Viftrup, M. P. Johansson, T. B. Poulsen, L. Holmegaard, V. Kumarappan, K. A. Jørgensen, H. Stapelfeldt, " Manipulating the Torsion of Molecules by Strong Laser Pulses" Phys. Rev. Lett. 2009, 102, 073007.

15. T. B. Poulsen, G. Dickmeiss, J. Overgaard, K. A. Jørgensen, "Organocatalytic Asymmetric Synthesis of Versatile gamma-Lactams" Angew. Chem. Int. Ed. 2008, 47, 4687-4690.

14. T. B. Poulsen, K. A. Jørgensen, "Catalytic Asymmetric Friedel-Crafts Alkylation Reactions – Copper Showed the Way" Chem. Rev. 2008, 108, 2903-2915.

13. S. Santoro, T. B. Poulsen, K. A. Jørgensen, "Enantioselective Organocatalytic Substitution of αlfa-Cyanoacetates on Imidoyl Chlorides – Synthesis of Optically Active Ketimines" Chem. Commun. 2007, 5155-5157.

12. J. López-Cantarero, M. Belén Cid, T. B. Poulsen, M. Bella, J. L. G. Ruano, K. A. Jørgensen, "Intriguing Behaviour of Cinchona Alkaloids in the Enantioselective Organocatalytic Hydroxyamination of alfa-Substututed-alfa-Cyanoacetates" J. Org. Chem. 2007, 72, 7062-7065.

11. M. Bell, T. B. Poulsen, K. A. Jørgensen, "Organocatalytic Enantioselective Nucleophilic Vinylic Substitution by alfa-Substituted-alfa-Cyanoacetates under Phase-Transfer Conditions" J. Org. Chem. 2007, 72, 3053-3056.

10. T. B. Poulsen, L. Bernardi, J. Alemán, J. Overgaard, K. A. Jørgensen, "Organocatalytic Asymmetric alfa-Alkynylation of Cyclic beta-Ketoesters" J. Am. Chem. Soc. 2007, 129, 441-449.

9. T. B. Poulsen, L. Bernardi, M. Bell, K. A. Jørgensen, "Organocatalytic Enantioselective Nucleophilic Vinylic Substitution" Angew. Chem. Int. Ed. 2006, 45, 6551-6554.

8. T. B. Poulsen, M. Bell, K. A. Jørgensen, "Organocatalytic Asymmetric Allylic Carbon-Carbon Bond Formation" Org. Biomol. Chem. 2006, 4, 63-70 (Selected for Issue Cover).

7. T. B. Poulsen, C. Alemparte, K. A. Jørgensen, "Enantioselective Organocatalytic Allylic Amination" J. Am. Chem. Soc. 2005, 127i, 11614-11615.

6. W. Zhuang, T. B. Poulsen, K. A. Jørgensen, "A versatile catalyst for asymmetric reactions of carbonyl groups working purely by activation through hydrogen bonding: Mukaiyama-aldol, hetero Diels-Alder and Friedel-Crafts reactions" Org. Biomol. Chem. 2005, 3, 3284-3289.

5. K. A. Jørgensen, M. Marigo, J. Franzén, T. B. Poulsen, W. Zhuang, "Catalytic Asymmetric Synthesis of Optically Active Epoxides" Patent Application.

4. M. Marigo, J. Franzén, T. B. Poulsen, W. Zhuang, K. A. Jørgensen, "Asymmetric Organocatalytic Epoxidation of alfa,beta-Unsaturated Aldehydes with Hydrogen Peroxide" J. Am. Chem. Soc. 2005, 127, 6964-6965.

3. T. B. Poulsen, C. Alemparte, S. Saaby, M. Bella, K. A. Jørgensen, "Direct Organocatalytic and Highly Enantio- and Diastereoselective Mannich Reactions of alfa-Substituted-alfa-Cyanoacetates" Angew. Chem. Int. Ed.2005,44, 2896-2899.

Undergraduate (Aarhus - KA Jørgensen Laboratory)

2. N. Gathergood, K. Juhl, T. B. Poulsen, K. Thordrup, K. A. Jørgensen, "Direct catalytic asymmetric aldol reactions of pyruvates: scope and mechanism" Org. Biomol. Chem.2004, 2, 1077-1085.

1. A. Bøgevig, T. B. Poulsen, W. Zhuang, K. A. Jørgensen, "Formation of optically active functionalized beta-hydroxy nitrones using a proline catalyzed aldol

CONTACT

Phone: +45 61 14 18 44

Fax: +45 86 19 61 99

E-mail: thpou@chem.au.dk

ADDRESS

Dept. of Chemistry, Aarhus University

Langelandsgade 140

8000 Aarhus C, Denmark

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